| Friday November 21st, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Madeira | McNicholas | 58 | Madeira | 19 | W | 6:00 | | Box Score |
| Monday November 24th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Turpin at McNicholas | Turpin | 17 | McNicholas | 39 | W | 5:30 | | Box Score |
| Wednesday November 26th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Seton | McNicholas | 32 | Seton | 35 | L | 6:00 | | Box Score |
| Monday December 1st, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Batavia | McNicholas | 45 | Batavia | 37 | W | 6:00 | | Box Score |
| Wednesday December 3rd, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Chaminade Julienne | McNicholas | 40 | Chaminade Julienne | 38 | W | 6:00 | | Box Score |
| Saturday December 6th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Badin at McNicholas | Badin | 15 | McNicholas | 23 | W | 11:00 | | Box Score |
| Wednesday December 10th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Fenwick | McNicholas | 25 | Fenwick | 30 | L | 6:00 | | Box Score |
| Thursday December 18th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Indian Hill at McNicholas | Indian Hill | 11 | McNicholas | 41 | W | 5:00 | | Box Score |
| Saturday December 20th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| St. Ursula at McNicholas | St. Ursula | 34 | McNicholas | 41 | W | 11:00 | | Box Score |
| Saturday January 3rd, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Carroll at McNicholas | Carroll | 20 | McNicholas | 28 | W | 11:00 | | Box Score |
| Wednesday January 7th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Chaminade Julienne at McNicholas | Chaminade Julienne | 34 | McNicholas | 39 | W | 5:30 | | Box Score |
| Saturday January 10th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Anderson | McNicholas | 49 | Anderson | 39 | W | 11:00 | | Box Score |
| Monday January 12th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Roger Bacon at McNicholas | Roger Bacon | 20 | McNicholas | 52 | W | 5:30 | | Box Score |
| Wednesday January 14th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Fenwick at McNicholas | Fenwick | 33 | McNicholas | 35 | W | 5:30 | | Box Score |
| Saturday January 17th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Badin | McNicholas | 23 | Badin | 38 | L | 5:30 | | Box Score |
| Saturday January 24th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Milford at McNicholas | Milford | 47 | McNicholas | 49 | W | 11:00 | | Box Score |
| Wednesday January 28th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Alter | McNicholas | 17 | Alter | 40 | L | 5:30 | | Box Score |
| Saturday January 31st, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Carroll | McNicholas | 51 | Carroll | 28 | W | 11:00 | | Box Score |
| Monday February 2nd, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Mount Notre Dame at McNicholas | Mount Notre Dame | 37 | McNicholas | 21 | L | 5:30 | | Box Score |
| Thursday February 5th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Mercy McAuley at McNicholas | Mercy McAuley | 20 | McNicholas | 42 | W | 5:30 | | Box Score |
| Tuesday February 10th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Alter at McNicholas | Alter | | McNicholas | | W | 5:30 | | Box Score |
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