| Tuesday December 2nd, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Roger Bacon | McNicholas | 33 | Roger Bacon | 26 | W | 4:30 | | Box Score |
| Friday December 5th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Chaminade Julienne | McNicholas | 38 | Chaminade Julienne | 28 | W | 4:30 | | Box Score |
| Tuesday December 9th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Badin at McNicholas | Badin | 47 | McNicholas | 40 | L | 4:30 | | Box Score |
| Friday December 12th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Fenwick | McNicholas | 34 | Fenwick | 40 | L | 4:30 | | Box Score |
| Friday December 19th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Trotwood Madison at McNicholas | Trotwood Madison | 47 | McNicholas | 50 | W | 4:00 | overtime | Box Score |
| Saturday December 20th, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Elder at McNicholas | Elder | 45 | McNicholas | 30 | L | TBA | | Box Score |
| Monday December 22nd, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Newport Cent. Cath. | McNicholas | 59 | Newport Cent. Cath. | 32 | W | 4:30 | | Box Score |
| Wednesday December 31st, 2025 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Walnut Hills | McNicholas | 44 | Walnut Hills | 22 | W | 11:00 | | Box Score |
| Saturday January 3rd, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at St. Xavier | McNicholas | 32 | St. Xavier | 48 | L | 2:00 | | Box Score |
| Tuesday January 6th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Alter at McNicholas | Alter | 44 | McNicholas | 41 | L | 4:30 | | Box Score |
| Friday January 9th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Carroll at McNicholas | Carroll | 28 | McNicholas | 40 | W | 4:30 | | Box Score |
| Tuesday January 13th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at LaSalle | McNicholas | 31 | LaSalle | 24 | W | 4:30 | | Box Score |
| Friday January 16th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Chaminade Julienne at McNicholas | Chaminade Julienne | 40 | McNicholas | 57 | W | 4:30 | | Box Score |
| Saturday January 17th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Anderson | McNicholas | 42 | Anderson | 32 | W | 1:00 | | Box Score |
| Tuesday January 20th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Covington Catholic | McNicholas | 52 | Covington Catholic | 54 | L | 4:30 | | Box Score |
| Friday January 23rd, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Badin | McNicholas | 46 | Badin | 52 | L | 4:30 | | Box Score |
| Friday January 30th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Fenwick at McNicholas | Fenwick | 37 | McNicholas | 46 | W | 4:30 | | Box Score |
| Saturday January 31st, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| Turpin at McNicholas | Turpin | 43 | McNicholas | 47 | W | 4:30 | | Box Score |
| Tuesday February 3rd, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| MiamiValleyChristian at McNicholas | MiamiValleyChristian | 41 | McNicholas | 57 | W | 4:30 | | Box Score |
| Friday February 6th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Alter | McNicholas | | Alter | | W | 4:30 | | Box Score |
| Friday February 13th, 2026 |
| Teams | Visitor | Score | Home | Score | W-L | Time | Alternate Location | Game Box |
| McNicholas at Carroll | McNicholas | | Carroll | | W | 4:30 | | Box Score |
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